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Intramyocardial Transplantation of MSC-Loading Injectable Hydrogels after Myocardial Infarction in a Murine Model
JoVE Journal
Medicine
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JoVE Journal Medicine
Intramyocardial Transplantation of MSC-Loading Injectable Hydrogels after Myocardial Infarction in a Murine Model
DOI:

09:19 min

September 20, 2020

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Chapters

  • 00:05Introduction
  • 01:49Preparation of MSCs and Injectable Gelatin Hydrogels
  • 03:38In Situ MSC-loading and Three-dimensional in Vitro Culture
  • 04:29Induction of Myocardial Infarction in Mice
  • 05:44Intramyocardial Transplantation of MSC-loading GH Hydrogels
  • 06:37Results: Improving Stem Cell Retention and Engraftment with Injectable Hydrogels
  • 08:31Conclusion

Summary

Automatic Translation

Stem cell-based therapy has emerged as an efficient strategy to repair injured cardiac tissues after myocardial infarction. We provide an optimal in vivo application for stem cell transplantation using gelatin hydrogels that are able to be enzymatically cross-linked.

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