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将人类牙齿中的类器官确立为机械研究和再生疗法的有力工具

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Developmental Biology

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JoVE Journal Developmental Biology

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

Please note that all translations are automatically generated. Click here for the English version.

将人类牙齿中的类器官确立为机械研究和再生疗法的有力工具

DOI:

10.3791/63671-v

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11:02 min

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April 13, 2022

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Lara Hemeryck, Ivo Lambrichts, Annelies Bronckaers, Hugo Vankelecom

¹Laboratory of Tissue Plasticity in Health and Disease, Cluster of Stem Cell and Developmental Biology, Department of Development and Regeneration, Leuven Stem Cell Institute,KU Leuven (University of Leuven), ²Biomedical Research Institute (BIOMED),UHasselt, Hasselt University

Chapters

00:04Introduction
01:16Dental Follicle Dissociation
04:22Establishment of Tooth Organoid Culture
06:11Amplification and Passaging of Tooth Organoid Culture
08:47Results: Tooth Organoid Development, Characterization, and Validation
10:14Conclusion

Summary

Automatic Translation

我们提出了一种从人类牙齿开始开发上皮类器官培养物的方案。类器官具有强大的可膨胀性，可重现牙齿的上皮干细胞，包括其阿美巴分化能力。独特的类器官模型为研究人类牙齿（干细胞）生物学提供了一种有前途的工具，并为牙齿再生方法提供了前景。

Tags

Organoids Human Tooth Dental Stem Cells Regenerative Therapy Dental Tumors Enamel Formation Dental Follicles Dissociation

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