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Imágenes PET/MR no invasivas en un modelo ortotópico de ratón de carcinoma hepatocelular
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1Department of Diagnostic Radiology, School of Clinical Medicine, LKS Faculty of Medicine,The University of Hong Kong, 2Department of Oncology, MRC Oxford Institute for Radiation Oncology,University of Oxford, 3Department of Surgery, School of Clinical Medicine, HKU-SZH & LKS Faculty of Medicine,The University of Hong Kong, 4Department of Biomedical Engineering,The Chinese University of Hong Kong, 5Department of Diagnostic and Interventional Radiology,Kwong Wah Hospital
Chapters
- 00:04Introduction
- 01:06Subcutaneous Injection of Human Hepatocellular Carcinoma Cell Lines
- 01:45Orthotopic Liver Implantation and Hepatic Artery Ligation
- 04:00[18F] FMISO and [18F] FDG Injection
- 04:42PET/MR Acquisition
- 05:57Results: Effect of Hepatic Artery Ligation on Orthotopic Hepatocellular Carcinoma in Mice
- 07:02Conclusion
Aquí, presentamos un protocolo para crear xenoinjertos de carcinoma hepatocelular ortotópico con y sin ligadura de la arteria hepática y realizar imágenes no invasivas de tomografía por emisión de positrones (PET) de hipoxia tumoral utilizando [18 F] fluoromisonidazol ([18 F] FMISO) y [18 F] fluorodesoxiglucosa ([18F] FDG).
