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Cyclic Mechanical Loading for Inducing Tendinopathy in Rat Achilles Tendon

March 1st, 2024
1,2, 1,2, 1, 1, 1, 1,3, 1,3, 1,2,3,4
1Musculoskeletal Translational Innovation Initiative, Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 2Mechanical Engineering Department, Boston University, 3Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 4Department of Orthopaedic Surgery, Yerevan State Medical University

Summary
Automatic Translation

Denne protokol præsenterer et testsystem, der anvendes til at fremkalde kvantificerbare og kontrollerede træthedsskader i en rotteakillessene for en in vivo-model af overforbrugsinduceret tendinopati. Proceduren består i at fastgøre rottens ankel til en fælles aktuator, der udfører passiv ankeldorsiflexion med et specialskrevet MATLAB-script.

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