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Cyclic Mechanical Loading for Inducing Tendinopathy in Rat Achilles Tendon

March 1st, 2024
1,2, 1,2, 1, 1, 1, 1,3, 1,3, 1,2,3,4
1Musculoskeletal Translational Innovation Initiative, Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 2Mechanical Engineering Department, Boston University, 3Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 4Department of Orthopaedic Surgery, Yerevan State Medical University

Summary
Automatic Translation

Questo protocollo presenta un sistema di test utilizzato per indurre lesioni da fatica quantificabili e controllate in un tendine d'Achille di ratto per un modello in vivo di tendinopatia indotta da uso eccessivo. La procedura consiste nel fissare la caviglia del ratto a un attuatore articolare che esegue la flessione dorsale passiva della caviglia con uno script MATLAB scritto su misura.

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