Marc Diederich Department of Pharmacy, College of Pharmacy Seoul National University Biography Publications Institution JoVE Articles Marc Diederich has not added a biography. If you are Marc Diederich and would like to personalize this page please email our Author Liaison for assistance. Publications Natural Scaffolds in Anticancer Therapy and Precision Medicine Biotechnology Advances. May, 2018 | Pubmed ID: 29729870 Autophagy As a Pharmacological Target in Hematopoiesis and Hematological Disorders Biochemical Pharmacology. Jun, 2018 | Pubmed ID: 29656115 Biotinylation Enhances the Anticancer Effects of 15d‑PGJ2 Against Breast Cancer Cells International Journal of Oncology. Jun, 2018 | Pubmed ID: 29620161 Cardiac Glycoside Glucoevatromonoside Induces Cancer Type-Specific Cell Death Frontiers in Pharmacology. 2018 | Pubmed ID: 29545747 Stress-induced Cellular Responses in Immunogenic Cell Death: Implications for Cancer Immunotherapy Biochemical Pharmacology. Jul, 2018 | Pubmed ID: 29438676 The Fungal Metabolite Eurochevalierine, a Sequiterpene Alkaloid, Displays Anti-Cancer Properties Through Selective Sirtuin 1/2 Inhibition Molecules (Basel, Switzerland). Feb, 2018 | Pubmed ID: 29401749 Cytostatic Hydroxycoumarin OT52 Induces ER/Golgi Stress and STAT3 Inhibition Triggering Non-canonical Cell Death and Synergy with BH3 Mimetics in Lung Cancer Cancer Letters. Mar, 2018 | Pubmed ID: 29247826 The Dialkyl Resorcinol Stemphol Disrupts Calcium Homeostasis to Trigger Programmed Immunogenic Necrosis in Cancer Cancer Letters. Mar, 2018 | Pubmed ID: 29246646 Anti-cancer Effects of Naturally Derived Compounds Targeting Histone Deacetylase 6-related Pathways Pharmacological Research. Mar, 2018 | Pubmed ID: 29133216 The Forty-Sixth Euro Congress on Drug Synthesis and Analysis: Snapshot Molecules (Basel, Switzerland). Oct, 2017 | Pubmed ID: 29143778 Anticancer and Immunogenic Properties of Cardiac Glycosides Molecules (Basel, Switzerland). Nov, 2017 | Pubmed ID: 29117117 Tubulin-binding Anticancer Polysulfides Induce Cell Death Via Mitotic Arrest and Autophagic Interference in Colorectal Cancer Cancer Letters. 12, 2017 | Pubmed ID: 28943451 Anti-proliferative, Cytotoxic and NF-ĸB Inhibitory Properties of Spiro(Lactone-Cyclohexanone) Compounds in Human Leukemia Anticancer Research. 09, 2017 | Pubmed ID: 28870958 Metabolomic Tools to Assess the Chemistry and Bioactivity of Endophytic Aspergillus Strain Chemistry & Biodiversity. Oct, 2017 | Pubmed ID: 28672096 Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity Against Cancer Cell Lines Journal of Medicinal Chemistry. Jun, 2017 | Pubmed ID: 28475330 Cardiac Glycosides: From Molecular Targets to Immunogenic Cell Death Biochemical Pharmacology. Feb, 2017 | Pubmed ID: 27553475 Natural Compound Histone Deacetylase Inhibitors (HDACi): Synergy with Inflammatory Signaling Pathway Modulators and Clinical Applications in Cancer Molecules (Basel, Switzerland). Nov, 2016 | Pubmed ID: 27886118 The Eighth Central European Conference "Chemistry Towards Biology": Snapshot Molecules (Basel, Switzerland). Oct, 2016 | Pubmed ID: 27763518 4α-Methylated Steroids with Cytotoxic Activity from the Soft Coral Litophyton Mollis Steroids. 11, 2016 | Pubmed ID: 27553729 Garlic-derived Natural Polysulfanes As Hydrogen Sulfide Donors: Friend or Foe? Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Sep, 2016 | Pubmed ID: 27430419 Non-canonical Programmed Cell Death Mechanisms Triggered by Natural Compounds Seminars in Cancer Biology. 10, 2016 | Pubmed ID: 27262793 Discovery and Characterization of Isofistularin-3, a Marine Brominated Alkaloid, As a New DNA Demethylating Agent Inducing Cell Cycle Arrest and Sensitization to TRAIL in Cancer Cells Oncotarget. Apr, 2016 | Pubmed ID: 27006469 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd Edition) Autophagy. Jan, 2016 | Pubmed ID: 26799652 4-Hydroxybenzoic Acid Derivatives As HDAC6-specific Inhibitors Modulating Microtubular Structure and HSP90α Chaperone Activity Against Prostate Cancer Biochemical Pharmacology. Jan, 2016 | Pubmed ID: 26549368 Natural and Synthetic Flavonoids: Structure-Activity Relationship and Chemotherapeutic Potential for the Treatment of Leukemia Critical Reviews in Food Science and Nutrition. Jul, 2016 | Pubmed ID: 26463658 Perspectives in Medicinal Chemistry: DNA Methylation and Demethylation Mechanisms As Therapeutic Targets? Current Topics in Medicinal Chemistry. 2016 | Pubmed ID: 26459805 Novel Pharmaceutical Approaches by Natural Compound-Derived Epigenetic Regulators: Epigenetic Readers, Writers and Erasers As Therapeutic Targets Current Topics in Medicinal Chemistry. 2016 | Pubmed ID: 26459804 Epigenetic Alterations As a Universal Feature of Cancer Hallmarks and a Promising Target for Personalized Treatments Current Topics in Medicinal Chemistry. 2016 | Pubmed ID: 26303418 Roles of Apoptosis and Cellular Senescence in Cancer and Aging Current Drug Targets. 2016 | Pubmed ID: 25642721 Cytotoxic, Antiproliferative and Pro-Apoptotic Effects of 5-Hydroxyl-6,7,3',4',5'-Pentamethoxyflavone Isolated from Lantana Ukambensis Nutrients. Dec, 2015 | Pubmed ID: 26690473 Coffee Provides a Natural Multitarget Pharmacopeia Against the Hallmarks of Cancer Genes & Nutrition. Nov, 2015 | Pubmed ID: 26577824 Flavonoid Glycosides from Olax Mannii: Structure Elucidation and Effect on the Nuclear Factor Kappa B Pathway Journal of Ethnopharmacology. Dec, 2015 | Pubmed ID: 26475120 2,5-Dimethyl-celecoxib Inhibits Cell Cycle Progression and Induces Apoptosis in Human Leukemia Cells The Journal of Pharmacology and Experimental Therapeutics. Nov, 2015 | Pubmed ID: 26330537 Signal Transducers and Activators of Transcription (STAT) Regulatory Networks in Marine Organisms: From Physiological Observations Towards Marine Drug Discovery Marine Drugs. Aug, 2015 | Pubmed ID: 26262624 Epipolythiodiketopiperazines from the Marine Derived Fungus Dichotomomyces Cejpii with NF-κB Inhibitory Potential Marine Drugs. Aug, 2015 | Pubmed ID: 26258781 Effects of Natural Products on Mcl-1 Expression and Function Current Medicinal Chemistry. 2015 | Pubmed ID: 26179996 Bispecific Antibodies: an Innovative Arsenal to Hunt, Grab and Destroy Cancer Cells Current Pharmaceutical Biotechnology. 2015 | Pubmed ID: 25941884 A Survey of Marine Natural Compounds and Their Derivatives with Anti-cancer Activity Reported in 2012 Molecules (Basel, Switzerland). Apr, 2015 | Pubmed ID: 25903364 Natural Compounds and Pharmaceuticals Reprogram Leukemia Cell Differentiation Pathways Biotechnology Advances. Nov, 2015 | Pubmed ID: 25886879 Cancer-type-specific Crosstalk Between Autophagy, Necroptosis and Apoptosis As a Pharmacological Target Biochemical Pharmacology. Mar, 2015 | Pubmed ID: 25562745 Dual Induction of Mitochondrial Apoptosis and Senescence in Chronic Myelogenous Leukemia by Myrtucommulone A Anti-cancer Agents in Medicinal Chemistry. 2015 | Pubmed ID: 25469628 Celecoxib Prevents Curcumin-induced Apoptosis in a Hematopoietic Cancer Cell Model Molecular Carcinogenesis. Oct, 2015 | Pubmed ID: 24798089 Antagonistic Role of Natural Compounds in MTOR-mediated Metabolic Reprogramming Cancer Letters. Jan, 2015 | Pubmed ID: 24530513 Hybrid Curcumin Compounds: a New Strategy for Cancer Treatment Molecules (Basel, Switzerland). Dec, 2014 | Pubmed ID: 25514225 Non-edible Plants As an Attractive Source of Compounds with Chemopreventive Potential Journal of Cancer Prevention. Mar, 2014 | Pubmed ID: 25337566 Valproic Acid Regulates Erythro-megakaryocytic Differentiation Through the Modulation of Transcription Factors and MicroRNA Regulatory Micro-networks Biochemical Pharmacology. Nov, 2014 | Pubmed ID: 25241289 Eurycomanone and Eurycomanol from Eurycoma Longifolia Jack As Regulators of Signaling Pathways Involved in Proliferation, Cell Death and Inflammation Molecules (Basel, Switzerland). Sep, 2014 | Pubmed ID: 25230121 Metabolism 2014--alterations of Metabolic Pathways As Therapeutic Targets Biochemical Pharmacology. Nov, 2014 | Pubmed ID: 25219325 P53 and Sirt1: Routes of Metabolism and Genome Stability Biochemical Pharmacology. Nov, 2014 | Pubmed ID: 25218422 Synthesis and Bioactivity of Novel Amino-pyrazolopyridines European Journal of Medicinal Chemistry. Oct, 2014 | Pubmed ID: 25108361 Energy Restriction Mimetic Agents to Target Cancer Cells: Comparison Between 2-deoxyglucose and Thiazolidinediones Biochemical Pharmacology. Nov, 2014 | Pubmed ID: 25083915 Regulation of Epigenetic Traits of the Glutathione S-transferase P1 Gene: from Detoxification Toward Cancer Prevention and Diagnosis Frontiers in Pharmacology. 2014 | Pubmed ID: 25076909 Novel Inhibitors of Human Histone Deacetylases: Design, Synthesis and Bioactivity of 3-alkenoylcoumarines Bioorganic & Medicinal Chemistry Letters. Aug, 2014 | Pubmed ID: 25042254 Modulatory Roles of Glycolytic Enzymes in Cell Death Biochemical Pharmacology. Nov, 2014 | Pubmed ID: 25034412 Methylenedioxy Flavonoids: Assessment of Cytotoxic and Anti-cancer Potential in Human Leukemia Cells European Journal of Medicinal Chemistry. Sep, 2014 | Pubmed ID: 25016375 Plumbagin Modulates Leukemia Cell Redox Status Molecules (Basel, Switzerland). Jul, 2014 | Pubmed ID: 25014531 Inhibitory Effect of St. John׳s Wort Oil Macerates on TNFα-induced NF-κB Activation and Their Fatty Acid Composition Journal of Ethnopharmacology. Sep, 2014 | Pubmed ID: 24993886 5-aza-2'-deoxycytidine-mediated C-myc Down-regulation Triggers Telomere-dependent Senescence by Regulating Human Telomerase Reverse Transcriptase in Chronic Myeloid Leukemia Neoplasia (New York, N.Y.). Jun, 2014 | Pubmed ID: 24970385 Epigenetic Modulators from "The Big Blue": a Treasure to Fight Against Cancer Cancer Letters. Sep, 2014 | Pubmed ID: 24964131 Properly Substituted Analogues of BIX-01294 Lose Inhibition of G9a Histone Methyltransferase and Gain Selective Anti-DNA Methyltransferase 3A Activity PloS One. 2014 | Pubmed ID: 24810902 Bis(4-hydroxy-2H-chromen-2-one): Synthesis and Effects on Leukemic Cell Lines Proliferation and NF-κB Regulation Bioorganic & Medicinal Chemistry. Jun, 2014 | Pubmed ID: 24775915 Plant-derived Epigenetic Modulators for Cancer Treatment and Prevention Biotechnology Advances. Nov, 2014 | Pubmed ID: 24699435 From Nature to Bedside: Pro-survival and Cell Death Mechanisms As Therapeutic Targets in Cancer Treatment Biotechnology Advances. Nov, 2014 | Pubmed ID: 24681093 Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells Journal of Medicinal Chemistry. Feb, 2014 | Pubmed ID: 24387159 Synthetic Polysulfane Derivatives Induce Cell Cycle Arrest and Apoptotic Cell Death in Human Hematopoietic Cancer Cells Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Feb, 2014 | Pubmed ID: 24157544 Antiproliferative and Proapoptotic Activities of 4-hydroxybenzoic Acid-based Inhibitors of Histone Deacetylases Cancer Letters. Feb, 2014 | Pubmed ID: 24080339 Venus Flytrap (Dionaea Muscipula Solander Ex Ellis) Contains Powerful Compounds That Prevent and Cure Cancer Frontiers in Oncology. 2013 | Pubmed ID: 23971004 Metabolism and Cancer: Old and New Players International Journal of Cell Biology. 2013 | Pubmed ID: 23864859 Long and Short Non-coding RNAs As Regulators of Hematopoietic Differentiation International Journal of Molecular Sciences. Jul, 2013 | Pubmed ID: 23860209 Selective Modulation of the Glucocorticoid Receptor Can Distinguish Between Transrepression of NF-κB and AP-1 Cellular and Molecular Life Sciences : CMLS. Jun, 2013 | Pubmed ID: 23784308 Natural Compounds As Regulators of the Cancer Cell Metabolism International Journal of Cell Biology. 2013 | Pubmed ID: 23762063 Parkinson's Disease: a Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress International Journal of Molecular Sciences. Jan, 2013 | Pubmed ID: 23348931 Breakthrough in Tracking Tumor Erythropoietin Receptor Expression Chinese Clinical Oncology. Dec, 2012 | Pubmed ID: 25841402 Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts Jin-Young Lee*1, Aloran Mazumder*1, Marc Diederich1 1Department of Pharmacy, College of Pharmacy, Seoul National University JoVE 57490 Recherche en cancérologie
Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts Jin-Young Lee*1, Aloran Mazumder*1, Marc Diederich1 1Department of Pharmacy, College of Pharmacy, Seoul National University JoVE 57490 Recherche en cancérologie