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Metabolomic Analysis of Rat Brain by High Resolution Nuclear Magnetic Resonance Spectroscopy of Tissue Extracts
 

Metabolomic Analysis of Rat Brain by High Resolution Nuclear Magnetic Resonance Spectroscopy of Tissue Extracts

Article DOI: 10.3791/51829-v • 09:01 min • September 21st, 2014
September 21st, 2014 •
1, 2, 1
1Centre de Résonance Magnétique Biologique et Médicale, UMR 7339 CNRS, Faculté de Médecine, Aix-Marseille Université, 2Centre de Recherches en Oncologie Biologique et Oncopharmacologie, UMR 911 INSERM, Faculté de Médecine, Aix-Marseille Université

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résumé
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The neurochemistry of mammalian brain is changed in many neurological and systemic diseases. Characteristic profiles of cerebral metabolites can be efficiently obtained based on crude extracts of brain tissue. To this end, high-resolution NMR spectroscopy is employed, enabling detailed quantitative analysis of metabolite concentrations (metabolomics).

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Metabolomic Analysis Rat Brain High Resolution Nuclear Magnetic Resonance Spectroscopy Tissue Extracts Gene Expression RNA Protein Levels Biological Processes Disease Genomics Proteomics Metabolite Pool Metabolomics Small-molecule Complement Metabolism Spectroscopic Techniques Biochemical Pathways Experimental Protocol NMR Spectroscopy Quantification Of Tissue Metabolites
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