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A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
 

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Article DOI: 10.3791/54136-v • 09:37 min • July 14th, 2016
July 14th, 2016 •
*1, *1, *1, 2, 2, 1,2
1Department of Environmental Health Sciences, Yale University School of Medicine, 2Department of Ophthalmology, Yale University School of Medicine
* These authors contributed equally

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résumé
Automatic Translation

A reverse-genetics approach to understanding gene families associated with human disease is presented, using mouse as a model system, and the subsequent mouse phenotyping schedule is described. Because mice defective in a gene of interest, HtrA2, manifested Parkinsonian symptoms, the phenotyping regimen is focused on identifying neurological defects.

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Keywords: Phenotyping Genetically Modified Mice Aging Hind Limb Test Weanling Observation Test Proximal Hind Limb Muscle Strength Muscle Weakness Muscle Fatigue Behavioral Phenotypes Cellular Phenotypes Human Disease Models Mouse Models Acclimation Weight Recording Video Recording Standardized Testing Setup
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