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Cancer Research

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JoVE Journal Cancer Research
How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases
 

How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases

Article DOI: 10.3791/54230-v • 13:18 min • September 20th, 2016
September 20th, 2016 •
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1Departamento de Genética, Facultad de Medicina, Universidad de la República (UDELAR), 2Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, 3School of Biological, Biomedical & Environmental Sciences, University of Hull

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Here we explain a protocol for modelling the biophysical microenvironment where crosslinking and increased stiffness of the basement membrane (BM) induced by advanced glycation endproducts (AGEs) has pathological relevance.

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Keywords: Basement Membrane Stiffness Thickness Advanced Glycation Prostate Cancer Metastasis Age-related Pathologies Metabolic Diseases Cell Invasion 3D Cell Culture Cross-linking Biophysical Trigger
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