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Bioengineering

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JoVE Journal Bioengineering
Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting
 

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

Article DOI: 10.3791/55440-v • 11:58 min • March 8th, 2018
March 8th, 2018 •
1, 1, 1, 1, 1,2,3, 1,2,3, 1,2,3
1Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke, 2Sherbrooke Molecular Imaging Center (CIMS), Université de Sherbrooke, 3Sherbrooke Institute of Pharmacology

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Viral-derived peptides coupled to antibody-conjugates (ACs) is an approach gaining momentum due to the potential of delivering molecular payloads with increased tumor cell accumulation. Utilizing common methods to evaluate peptide conjugation, AC and payload intracellular accumulation, and tumor targeting, this protocol helps researchers during the key initial development phases.

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Keywords: Antibody-conjugates Viral-derived Peptides Cellular Accumulation Tumor Targeting PET Imaging Nuclear Localization TF1A Cells Colic-acid Monoclonal Antibodies Trypsin EDTA RPMI1640 PFA Sucrose Triton X-100 Alexa Fluor 647
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