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Genetics

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JoVE Journal Genetics
基于纠错 DNA 和 RNA 测序的稀有事件检测方法
 
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基于纠错 DNA 和 RNA 测序的稀有事件检测方法

Article DOI: 10.3791/57509-v • 10:36 min • August 3rd, 2018
August 3rd, 2018 •
*1,2, *1,2, 1,2, 1,2
1Department of Pediatrics, Division of Hematology and Oncology, Washington University School of Medicine, 2Center for Genome Sciences and Systems Biology, Washington University School of Medicine
* These authors contributed equally

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下一代测序 (0.5–2.0%) 是基因组特征的有力工具, 受平台高错误率的限制。我们描述了我们的错误纠正排序方法, 使我们能够避免的误差率和检测突变的变异等位基因分数罕见的0.0001。

Tags

遗传学 问题 138 罕见的事件检测 错误纠正排序 生物信息学 基因组学 早期发现 分子标记
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