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Bioengineering

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JoVE Journal Bioengineering
A Reliable and Reproducible Critical-Sized Segmental Femoral Defect Model in Rats Stabilized with a Custom External Fixator
 

A Reliable and Reproducible Critical-Sized Segmental Femoral Defect Model in Rats Stabilized with a Custom External Fixator

Article DOI: 10.3791/59206-v • 08:20 min • March 24th, 2019
March 24th, 2019 •
1, 2, 1, 1, 1, 1,2, 3, 1
1Department of Orthopedics and Rehabilitation, University of Wisconsin-Madison, 2Department of Biomedical Engineering, University of Wisconsin-Madison, 3Summit Orthopedics

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In vivo mammalian models of critical-sized bone defects are essential for researchers studying healing mechanisms and orthopedic therapies. Here, we introduce a protocol for the creation of reproducible, segmental, femoral defects in rats stabilized using external fixation.

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Reliable Reproducible Critical-sized Segmental Femoral Defect Model Rats Custom External Fixator Surgical Protocol Bone Healing Regenerative Therapies Longitudinal Healing Studies Translatable Traumatic Critical-sized Diaphysial Bone Defects External Fixation Drilling Pins High Rotations Per Minute Low Pressure Lateral Cortex Bone Morphogenetic Protein Tube Bone Graft Kit Collagen Sponge Five By Three By Three Millimeter Defect Bone Morphogenetic Protein-2 Solution
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