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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
 

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Article DOI: 10.3791/61464-v • 08:50 min • June 24th, 2020
June 24th, 2020 •
1, 1, 2, 1, 3, 1,4
1Division of Neonatology, Stead Family Department of Pediatrics, University of Iowa, 2Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, University of Iowa, 3Division of Neonatology, Department of Pediatrics, Vanderbilt University, 4Department of Microbiology & Immunology, University of Iowa

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We developed a model of chorioamnionitis to simulate fetal exposure to maternal inflammation (FEMI) without complications of live organisms to examine the effects of FEMI on development of the offspring’s intestinal tract. This allows for study of mechanistic causes for development of intestinal injury following chorioamnionitis.

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Keywords: Fetal Exposure Maternal Inflammation FEMI Necrotizing Enterocolitis NEC Chorioamnionitis LPS Injection Pregnant Mouse Intestinal Development RNA Quantification Histology
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