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Bioengineering

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JoVE Journal Bioengineering
Establishment of a Surgically-induced Model in Mice to Investigate the Protective Role of Progranulin in Osteoarthritis
 

Establishment of a Surgically-induced Model in Mice to Investigate the Protective Role of Progranulin in Osteoarthritis

Article DOI: 10.3791/50924-v • 07:58 min • February 25th, 2014
February 25th, 2014 •
1, 1, 2
1Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 2Department of Orthopaedic Surgery, New York University Medical Center

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We describe a protocol for the destabilization of the medial meniscus (DMM) model in mice, an effective tool for osteoarthritis (OA) research. In addition, we have demonstrated that deficiency of progranulincan exaggerate OA development and progression by using this model, indicating that progranulin plays a protective role in the pathogenesis of OA.

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Surgically-induced Model Mice Investigate Protective Role Progranulin Osteoarthritis Destabilization Of Medial Meniscus (DMM) Model Pathophysiological Roles Arthritis Associated Molecules Pathogenesis Visualized Protocol Complicated Model Wildtype Mice Progranulin (PGRN)-/- Mice Inducing DMM Model Onset Of OA Surgically Induced Model Sham Operation DMM Operation Menisco-tibial Ligament Osteoarthritis Severity Histological Assay Safranin O Staining OA-associated Genes Degradation Of Cartilage Extracellular Matrix Molecules Osteophyte Formation
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