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Genetics

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JoVE Journal Genetics
Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice
 

Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice

Article DOI: 10.3791/59320-v • 08:13 min • April 10th, 2019
April 10th, 2019 •
*1,2, *1, *1,2, 2, 1, 1
1Vascular Biology Center, Medical College of Georgia, Augusta University, 2Renji Hospital, School of Medicine, Shanghai Jiaotong University
* These authors contributed equally

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Here, we present a protocol to transiently improve cardiac function in Duchenne muscular dystrophy mice by transplanting exosomes derived from normal myogenic progenitor cells.

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Keywords: Duchenne Muscular Dystrophy Exosomes Myogenic Progenitor Cells Cardiac Function Echocardiography Ultracentrifugation Intramyocardial Transplantation
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