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Immunology and Infection

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JoVE Journal Immunology and Infection
Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin
 

Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin

Article DOI: 10.3791/60067-v • 10:21 min • September 12th, 2019
September 12th, 2019 •
1,2,3, 4, 4, 4, 1,2
1Department of Molecular and Cellular Physiology, Albany Medical College, 2The IBD Center, Division of Gastroenterology, Department of Medicine, Albany Medical College, 3Department of Geriatrics, School of Medicine and Health Science, University of North Dakota, 4Department of Neuroscience and Experimental Therapeutics, Albany Medical College

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In this study, we describe a detailed procedure of TNBS-mediated intestinal fibrosis, which exhibits comparable pathophysiology to Crohn's fibrosis. We also discuss this approach in light of rapamycin facilitated inhibitory effects on intestinal fibrosis.

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Keywords: TNBS Intestinal Fibrosis Crohn's Disease Rapamycin Extracellular Matrix Tissue Repair Tissue Regeneration Colitis Lamina Propria Collagenase DNASE1
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