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Journal / Genetics / Mapping Alzheimer's Disease Variants to Their…
JoVE Journal
Genetics

This Contenuto is Open Access.

JoVE Journal Genetics
Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
 

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Article DOI: 10.3791/60428-v • 04:41 min • January 9th, 2020
January 9th, 2020 •
1,2, 3, *3,4, *1,2
1Department of Genetics, University of North Carolina, 2Neuroscience Center, University of North Carolina, 3Thurston Arthritis Research Center, University of North Carolina, 4Department of Cell Biology and Physiology, University of North Carolina
* These authors contributed equally

Capitoli

Riepilogo
Automatic Translation

We present a protocol to identify functional implications of non-coding variants identified by genome-wide association studies (GWAS) using three-dimensional chromatin interactions.

Tags

Keywords: Alzheimer's Disease GWAS Chromatin Configuration Computational Analysis Target Genes SNPs Hi-C Gene Expression Cell-type Expression Gene Annotation Enrichment
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