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Neuroscience

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JoVE Journal Neuroscience
Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage
 

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

Article DOI: 10.3791/64286-v • 07:13 min • February 10th, 2023
February 10th, 2023 •
1, 1, 1,2
1Department of Audiology and Speech-Language Pathology, MacKay Medical College, 2Institute of Biomedical Sciences, MacKay Medical College

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Automatic Translation

Here, we present a protocol for a mouse model of noise-induced hearing loss (NIHL). To induce NIHL, we developed a new and simple device using corrugated plastic, a rat trap cage, and a speaker. Auditory brainstem response and immunofluorescence imaging were employed to assess the hearing function and outer hair cell damage, respectively.

Tags

Keywords: Noise-induced Hearing Loss Mice ABR Outer Hair Cell Damage Experimental Conditions Hearing Function Assessment Animal Model Sound Exposure Hearing Threshold
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