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Journal / Neuroscience / Efficient Derivation of Human Neuronal…
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Neuroscience

This Conteúdo is Open Access.

JoVE Journal Neuroscience
Efficient Derivation of Human Neuronal Progenitors and Neurons from Pluripotent Human Embryonic Stem Cells with Small Molecule Induction
 

Efficient Derivation of Human Neuronal Progenitors and Neurons from Pluripotent Human Embryonic Stem Cells with Small Molecule Induction

Article DOI: 10.3791/3273-v • 10:48 min • October 28th, 2011
October 28th, 2011 •
1,2, 3,4, 1,2, 1,2,5, 1,2,6, 1,2
1San Diego Regenerative Medicine Institute, 2Xcelthera, 3Department of Neurosurgery, Harvard Medical School, 4Division of SCI Research, VA Boston Healthcare System, 5Program in Stem Cell & Regenerative Biology, Sanford-Burnham Medical Research Institute, 6La Jolla IVF

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Resumo
Automatic Translation

We have established a protocol for induction of neuroblasts direct from pluripotent human embryonic stem cells maintained under defined conditions with small molecules, which enables derivation of a large supply of human neuronal progenitors and neuronal cell types in the developing CNS for neural repair.

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Human Neuronal Progenitors Neurons Pluripotent Human Embryonic Stem Cells Small Molecule Induction Cell-based Therapies Central Nervous System (CNS) Neural Stem Cells Expansion Ability Plasticity Trophic And Neuroprotective Molecules Pluripotent HESCs Neurological Disorders Differentiation Potential Developmental Study Clinical Translation Multi-lineage Inclination Germ Layer
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