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JoVE Journal Neuroscience
Directed Dopaminergic Neuron Differentiation from Human Pluripotent Stem Cells
 

Directed Dopaminergic Neuron Differentiation from Human Pluripotent Stem Cells

Article DOI: 10.3791/51737-v • 06:40 min • September 15th, 2014
September 15th, 2014 •
*1, *1, 1,2
1Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 2Department of Obstetrics and Gynecology, Stanford University School of Medicine
* These authors contributed equally

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We, based on knowledge from developmental biology and published research, developed an optimized protocol to efficiently generate A9 midbrain dopaminergic neurons from both human embryonic stem cells and human induced pluripotent stem cells, which would be useful for disease modeling and cell replacement therapy for Parkinson’s disease.

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Keywords: Dopaminergic Neurons Pluripotent Stem Cells Parkinson's Disease Cell Replacement Therapy Floor Plate Ventral Midline Neural Development Differentiation Human Embryonic Stem Cells Human Induced Pluripotent Stem Cells In Vitro Disease Modeling Drug Screening Cell Transplantation
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