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Tibial Nerve Transection - A Standardized Model for Denervation-induced Skeletal Muscle Atrophy in Mice
 

Tibial Nerve Transection - A Standardized Model for Denervation-induced Skeletal Muscle Atrophy in Mice

Article DOI: 10.3791/50657-v • 10:50 min • November 3rd, 2013
November 3rd, 2013 •
1, 2
1Keenan Research Centre of the LiKaShing Knowledge Institute, St Michaels Hospital, 2Department of Surgery, McMaster University

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Automatic Translation

The tibial nerve transection model is a well-tolerated, validated, and reproducible model of skeletal muscle atrophy. The model surgical protocol is described and demonstrated in C57Black6 mice.  

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Keywords: Tibial Nerve Transection Denervation-induced Skeletal Muscle Atrophy Rodent Model Gastrocnemius Muscle Muscle Fiber Type C57Black6 Mouse
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