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JoVE Journal Bioengineering
Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion
 

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion

Article DOI: 10.3791/51321-v • 05:48 min • March 18th, 2014
March 18th, 2014 •
1,2, 1
1Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, 2Institute of Medical Biology, A*Star, Singapore

Capítulos

Resumo
Automatic Translation

Tissue engineered fibroblast-derived native matrix is an emerging tool to generate a stromal substrate which supports epithelial cell proliferation and differentiation. Here a protocol applying this methodology to assess the impact of different stromal cell types on tumor cell biology is presented.

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Tissue Engineering Tumor Stromal Microenvironment Cancer Cell Invasion 3D Organotypic Cultures Epithelial Cells Matrix Mesenchymal Cells Fibroblasts Rat Tail Type I Collagen Engelbreth-Holm-Swarm Mouse Sarcoma Cells Substrates Matrix Composition Basement Membrane Components Growth Factors Native Matrices Primary Dermal Fibroblasts Genetic Blistering Disorder Recessive Dystrophic Epidermolysis Bullosa Native Matrix Protocol Cellular Differentiation
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