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Immunology and Infection

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JoVE Journal Immunology and Infection
Isolation and Transplantation of Different Aged Murine Thymic Grafts.
 

Isolation and Transplantation of Different Aged Murine Thymic Grafts.

Article DOI: 10.3791/52709-v • 05:47 min • May 13th, 2015
May 13th, 2015 •
*1, *1, 1, 1
1Department of Microbiology and Immunology, University of North Carolina at Chapel Hill
* These authors contributed equally

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This report provides a detailed description of transplanting murine thymi from different aged donor mice under the kidney capsule of immunodeficient mouse recipients. The goal of this approach is to model T cell development and thymic selection events in vivo.

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Thymic Graft Thymic Selection Thymic Transplantation Thymic Function T Cell Development Immune Reconstitution Scid Recipient Age-dependent Thymic Events
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