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A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
 

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis

Article DOI: 10.3791/52858-v • 05:06 min • October 24th, 2015
October 24th, 2015 •
1,2, 1, 1, 1, 1,2
1Department of Biological Sciences, Hunter College of the City University of New York, 2Departments of Biology and Biochemistry, The Graduate Center of the City University of New York

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The metastatic spread of cancer is the major cause of cancer-related deaths. We provide an in-depth description of our survival surgery methodology for establishing a “patient-like” orthotopic syngeneic mouse model system for studying the mechanisms of metastasis in solid organ tumors.

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Patient-like Orthotopic Syngeneic Mouse Model Hepatocellular Carcinoma Metastasis Cancer-related Deaths Primary Tumor Underlying Mechanisms Animal Models Treatment Strategies Solid Organ Tumors Survival Surgical Implantation BNL 1ME A.7R.1 Mouse Hepatocellular Carcinoma Cells Liver Inbred Wild-type Immune Competent Laboratory Mouse Strain BALB/c Success And Reproducibility Biological Mechanisms
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