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Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research
 

Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research

Article DOI: 10.3791/55894-v • 10:10 min • November 2nd, 2018
November 2nd, 2018 •
1,2, 1,2,3,4,5,6,7
1Research Service, VA Western New York Healthcare System, 2Department of Ophthalmology, (Ross Eye Institute), Jacobs School of Medicine and Biomedical Sciences, University at Buffalo- SUNY, 3Pharmacology/Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo- SUNY, 4Physiology/Biophysics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo- SUNY, 5Neuroscience Program, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo- SUNY, 6The RNA Institute, University at Buffalo- SUNY, 7The SUNY Eye Institute

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Here we demonstrate a novel approach to using high resolution spectral-domain optical coherence tomography (HR-SD-OCT) to assist delivery of gene therapy agents into the subretinal space, assess its areal coverage, and characterize photoreceptor vitality.

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Keywords: Ultrahigh Resolution Mouse Optical Coherence Tomography Intraocular Injection Retinal Gene Therapy Subretinal Injection Vector Delivery Therapeutic Agent Toxicity Minimally Invasive Reproducible Real-time Observation Retinal Imaging Proptosis Scleral Depression Retinal Pigment Epithelium Subretinal Space Injection Outcomes OCT Imaging
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