JoVE Journal
Medicine
Medicine
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Chapters
Summary
Pancreatic islet microvascular vasomotion regulates islet blood distribution and maintains the physiological function of islet β cells. This protocol describes using a laser Doppler monitor to determine the functional status of pancreatic islet microvascular vasomotion in vivo and to assess the contributions of pancreatic islet microcirculation to pancreatic-related diseases.
Tags
Keywords: Laser Doppler Pancreatic Islet Microvascular Vasomotion In Vivo Circulatory Diabetes STZ Injection Blood Glucose Optical Probe
PLAYLIST
Diabetes is a condition that impairs the body’s ability to process blood glucose, otherwise known as blood sugar.
An Introduction to Metabolism
Underlying Causes of Diabetes
Diseases Associated with Diabetes
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Research • MedicineAn Ex Vivo Tissue Culture Model for Fibrovascular Complications in Proliferative Diabetic Retinopathy -
Research • Immunology and InfectionAn Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes -
Research • MedicineAssessment of Gastric Emptying in Non-obese Diabetic Mice Using a [13C]-octanoic Acid Breath Test
Diagnosis of Diabetes
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Research • MedicineCharacterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test -
Research • MedicineStudy of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT) -
Research • MedicineDetermining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT -
Research • MedicineLaser Doppler: A Tool for Measuring Pancreatic Islet Microvascular Vasomotion In Vivo -
Research • MedicineNear Infrared Optical Projection Tomography for Assessments of β-cell Mass Distribution in Diabetes Research
Investigational Treatment of Diabetes
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Research • BioengineeringTransient Expression in Red Beet of a Biopharmaceutical Candidate Vaccine for Type-1 Diabetes -
Research • BiologyRegulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes -
Research • Immunology and InfectionHigh-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
Studying Diabetes in Animal Models
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Research • MedicineA Zebrafish Model of Diabetes Mellitus and Metabolic Memory -
Research • Developmental BiologyAcute and Chronic Models of Hyperglycemia in Zebrafish: A Method to Assess the Impact of Hyperglycemia on Neurogenesis and the Biodistribution of Radiolabeled Molecules -
Research • MedicineHyperinsulinemic-Euglycemic Clamp in the Conscious Rat -
Research • NeuroscienceAlternate Immersion in Glucose to Produce Prolonged Hyperglycemia in Zebrafish
