JoVE Journal
Medicine
Medicine
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Chapters
Summary
Metabolic memory is the phenomenon by which diabetic complications persist and progress unimpeded even after euglycemia is achieved pharmaceutically. Here we describe a diabetes mellitus zebrafish model which is unique in that it allows for the examination of the mitotically transmissible epigenetic components of metabolic memory in vivo.
Tags
Zebrafish Model Diabetes Mellitus Metabolic Memory Glycemic Control Diabetic Complications Gene Expression Epigenetic Changes Environmental Stimuli Metabolic Memory Phenomenon Zebrafish Model Of Type I Diabetes Mellitus Secondary Complications Diabetic Retinopathy Diabetic Nephropathy Impaired Wound Healing Caudal Fin Regeneration Damaged Pancreas Euglycemic State Post-transplant Human Patients Pure Epigenetic Effects
PLAYLIST
Diabetes is a condition that impairs the body’s ability to process blood glucose, otherwise known as blood sugar.
An Introduction to Metabolism
Underlying Causes of Diabetes
Diseases Associated with Diabetes
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Research • MedicineAn Ex Vivo Tissue Culture Model for Fibrovascular Complications in Proliferative Diabetic Retinopathy -
Research • Immunology and InfectionAn Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes -
Research • MedicineAssessment of Gastric Emptying in Non-obese Diabetic Mice Using a [13C]-octanoic Acid Breath Test
Diagnosis of Diabetes
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Research • MedicineCharacterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test -
Research • MedicineStudy of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT) -
Research • MedicineDetermining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT -
Research • MedicineLaser Doppler: A Tool for Measuring Pancreatic Islet Microvascular Vasomotion In Vivo -
Research • MedicineNear Infrared Optical Projection Tomography for Assessments of β-cell Mass Distribution in Diabetes Research
Investigational Treatment of Diabetes
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Research • BioengineeringTransient Expression in Red Beet of a Biopharmaceutical Candidate Vaccine for Type-1 Diabetes -
Research • BiologyRegulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes -
Research • Immunology and InfectionHigh-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
Studying Diabetes in Animal Models
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Research • MedicineA Zebrafish Model of Diabetes Mellitus and Metabolic Memory -
Research • Developmental BiologyAcute and Chronic Models of Hyperglycemia in Zebrafish: A Method to Assess the Impact of Hyperglycemia on Neurogenesis and the Biodistribution of Radiolabeled Molecules -
Research • MedicineHyperinsulinemic-Euglycemic Clamp in the Conscious Rat -
Research • NeuroscienceAlternate Immersion in Glucose to Produce Prolonged Hyperglycemia in Zebrafish
