Immunology and Infection
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An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
Chapters
Summary
A simple and reliable diet-induced rodent animal model for nonalcoholic steatohepatitis (NASH) is described, achieved through non-SPF housing of the animals and administration of a specific high-fat diet. We describe identification of hepatic and adipose immune cell subsets to recapitulate human immunological conditions by exposing mice to environmental germs.
Tags
Advanced Murine Model Nonalcoholic Steatohepatitis Type 2 Diabetes Immunometabolism Immune Cells Obesity-induced Inflammation Adipose Tissue Steatohepatitis Hepatic Tissue Diet-induced Model Non-specific Pathogen-free Rodent Housing Metabolic Homeostasis Dissociated Cells Flow Cytometry Adipose Tissue Single-cell Suspension 70% Ethanol Central Incision Pleural Cavity Heart Saline Solution Peritoneal Cavity Epigonadal Adipose TissueRelated Videos
PLAYLIST
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Research • MedicineAn Ex Vivo Tissue Culture Model for Fibrovascular Complications in Proliferative Diabetic Retinopathy
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Research • Immunology and InfectionAn Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
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