JoVE
JoVE
Faculty Resource Center
Research
Behavior
Biochemistry
Biology
Bioengineering
Cancer Research
Chemistry
Developmental Biology
Engineering
Environment
Genetics
Immunology and Infection
Medicine
Neuroscience
JoVE Journal
JoVE Encyclopedia of Experiments
JoVE Chrome Extension
Education
Biology
Chemistry
Clinical
Engineering
Environmental Sciences
Pharmacology
Physics
Psychology
Statistics
JoVE Core
JoVE Science Education
JoVE Lab Manual
JoVE Quiz
JoVE Business
Videos Mapped to your Course
Authors
Librarians
High Schools
About
Sign-In
Sign In
Contact Us
Research
JoVE Journal
JoVE Encyclopedia of Experiments
Education
JoVE Core
JoVE Science Education
JoVE Lab Manual
High Schools
EN
EN - English
CN - 中文
DE - Deutsch
ES - Español
KR - 한국어
IT - Italiano
FR - Français
PT - Português
EN
EN - English
CN - 中文
DE - Deutsch
ES - Español
KR - 한국어
IT - Italiano
FR - Français
PT - Português
Close
Research
Behavior
Biochemistry
Bioengineering
Biology
Cancer Research
Chemistry
Developmental Biology
Engineering
Environment
Genetics
Immunology and Infection
Medicine
Neuroscience
Products
JoVE Journal
JoVE Encyclopedia of Experiments
Education
Biology
Chemistry
Clinical
Engineering
Environmental Sciences
Pharmacology
Physics
Psychology
Statistics
Products
JoVE Core
JoVE Science Education
JoVE Lab Manual
JoVE Quiz
JoVE Business
Videos Mapped to Your Course
Teacher Resources
Get in Touch
Instant Trial
Log In
EN
EN - English
CN - 中文
DE - Deutsch
ES - Español
KR - 한국어
IT - Italiano
FR - Français
PT - Português
Journal
/
Chemistry
/
以波马利多米德为基础的人种-PROTACs对E3泛基金的化学灭活
JoVE Journal
Chemistry
A subscription to JoVE is required to view this content.
Sign in or start your free trial.
JoVE Journal
Chemistry
Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
Please note that all translations are automatically generated.
Click here for the English version.
以波马利多米德为基础的人种-PROTACs对E3泛基金的化学灭活
DOI:
10.3791/59472-v
•
10:44 min
•
May 15, 2019
•
Stefanie Lindner*
1
,
Christian Steinebach*
2
,
Hannes Kehm
,
Martin Mangold
,
Michael Gütschow
,
Jan Krönke
1
Department of Internal Medicine III
,
University Hospital Ulm
,
2
Pharmaceutical Institute, Pharmaceutical Chemistry I
,
University of Bonn
Chapters
00:04
Title
00:52
Preparation of Proteolysis-targeting Chimera (PROTAC) Homodimer 8 (Compound 8)
04:32
Preparation of
tert
-Butyl
N
-(1-Methyl-2,6-dioxo-3-piperidyl)carbamate (Building Block 2 for Heterodimer 9)
05:52
Functional Validation of PROTAC Compounds
08:12
Results: Characterization and Efficacy of PROTACs
09:52
Conclusion
Summary
Automatic Translation
English (Original)
العربية (Arabic)
中文 (Chinese)
Nederlands (Dutch)
français (French)
Deutsch (German)
עברית (Hebrew)
italiano (Italian)
日本語 (Japanese)
한국어 (Korean)
português (Portuguese)
русский (Russian)
español (Spanish)
Türkçe (Turkish)
Automatic Translation
这项工作描述了一种基于波马利多米德的合成和表征,即一种基于双功能的同质性PROTAC,作为诱导E3泛性联苯基雷布龙(CRBN)的泛化和降解的新方法,该物质是沙利度胺类比靶的目标。
Tags
Keywords: CRBN Inhibition
PROTAC
Pomalidomide
Cereblon
E3 Ubiquitin Ligase
Protein Degradation
Chemical Synthesis
Glutarimide
3-fluorophthalic Anhydride
Diamine Linker
Article
Embed
ADD TO PLAYLIST
Usage Statistics
Related Videos
check_url/59472?article_type=v
折纸灵感的图案和可重构颗粒自组装
check_url/59472?article_type=v
自由基化学生物学的化学行为,生物标记开发
check_url/59472?article_type=v
隔离和脂质A的化学表征革兰氏阴性菌
check_url/59472?article_type=v
化学固定准备贴壁细胞的X射线荧光成像
check_url/59472?article_type=v
化学气相沉积的有机磁体,钒四氰
check_url/59472?article_type=v
对磷酸增强富集制备高度多孔配位聚合物涂层的孔聚合物石柱的
check_url/59472?article_type=v
化学溶液沉积在硅外延大孔石英薄膜的制备
check_url/59472?article_type=v
使用Photoredox催化剂蠕虫状胶束的简便合成可见光介导的分散聚合
check_url/59472?article_type=v
一种简单,低成本和强大的系统来测量氢气与水溶液化学反应放出的音量
check_url/59472?article_type=v
分离硫酸选择性结晶用双 - iminoguanidinium配体
Read Article