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Thoracic Spinal Cord Hemisection Surgery and Open-Field Locomotor Assessment in the Rat
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JoVE Journal Neuroscience
Thoracic Spinal Cord Hemisection Surgery and Open-Field Locomotor Assessment in the Rat

Thoracic Spinal Cord Hemisection Surgery and Open-Field Locomotor Assessment in the Rat

DOI:
10.3791/59738-v

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06:44 min

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June 26, 2019

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,
1Department of Neurosciences, Faculté de Médecine,Université de Montréal, 2Hôpital du Sacré-Cœur de Montréal, 3Groupe de Recherche sur le Système Nerveux Central (GRSNC),Université de Montréal

Chapters

  • 00:04Title
  • 00:32Thoracic Hemisection
  • 03:23Open-Field Testing and Locomotor Performance Scoring
  • 05:15Representative Results
  • 06:11Conclusion

Summary

Automatic Translation

Automatic Translation

The rat thoracic spinal hemisection is a valuable and reproducible model of unilateral spinal cord injury to investigate the neural mechanisms of locomotor recovery and treatment efficacy. This article includes a detailed step-by-step guide to perform the hemisection procedure and to assess locomotor performance in an open-field arena.

Tags

Keywords: Spinal Cord HemisectionLocomotor AssessmentRatThoracicLaminectomyLidocaineDura MaterMidlineDissecting KnifeAnterior Spinal Artery

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