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JoVE Journal Neuroscience
Lokomotorisk vurdering av 6-hydroksydopaminindusert voksen sebrafiskbasert Parkinsons sykdomsmodell
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Lokomotorisk vurdering av 6-hydroksydopaminindusert voksen sebrafiskbasert Parkinsons sykdomsmodell

Article DOI: 10.3791/63355-v • 07:32 min • December 28th, 2021
December 28th, 2021 •
1, 1, 1,2, 1, 1, 2, 1
1Collaborative Drug Discovery Research (CDDR) Group and Brain Degeneration and Therapeutics Group, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Cawangan Selangor, Kampus Puncak Alam, 2Department of Medicine, Faculty of Medicine, Universiti Malaya

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Den nåværende protokollen beskriver intracerebroventricular (ICV) injeksjon av voksen sebrafisk med nevrotoksisk 6-hydroksydopamin (6-OHDA) ved ventral diencephalon (Dn) og vurdering av svekkelse og påfølgende gjenoppretting av svømmeadferd postlesion ved hjelp av åpen tank test, som er ledsaget av analyse ved hjelp av en videosporing programvare.

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