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Performing Subretinal Injections in Rodents to Deliver Retinal Pigment Epithelium Cells in Suspension
 

Performing Subretinal Injections in Rodents to Deliver Retinal Pigment Epithelium Cells in Suspension

Article DOI: 10.3791/52247-v • 06:04 min • January 23rd, 2015
January 23rd, 2015 •
1,2, 1, 1, 1, 2, 1, 1,2
1Department of Cell and Molecular Biology, The Scripps Research Institute, 2Lowy Medical Research Institute

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Here we present a community accepted protocol in multimedia format for subretinally injecting a bolus of RPE cells in rats and mice. This approach can be used for determining rescue potentials, safety profiles, and survival capacities of grafted RPE cells upon implantation in animal models of retinal degeneration.

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Keywords: Subretinal Injection Retinal Pigment Epithelium RPE Cells Stem Cell-derived RPE Animal Model Age-related Macular Degeneration Photoreceptor Degeneration In Vivo Imaging
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