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Immunology and Infection

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JoVE Journal Immunology and Infection
Immunization of Adult Zebrafish for the Preclinical Screening of DNA-based Vaccines
 

Immunization of Adult Zebrafish for the Preclinical Screening of DNA-based Vaccines

Article DOI: 10.3791/58453-v • 05:39 min • October 30th, 2018
October 30th, 2018 •
*1, *1, 1,2, 1,3,4,5
1BioMediTech Institute, Faculty of Medicine and Life Sciences, University of Tampere, 2MedEngine Oy, 3Department of Pediatrics, Tampere University Hospital, 4Department of Children and Adolescents, Oulu University Hospital, 5PEDEGO Research Unit, Medical Research Center, University of Oulu
* These authors contributed equally

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Here we describe a protocol for the immunization of the adult zebrafish (Danio rerio) with a DNA-based vaccine and demonstrate the validation of a successful vaccination event. This method is suitable for the preclinical screening of vaccine candidates in various infection models.

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Keywords: Adult Zebrafish DNA-based Vaccines Preclinical Screening Tuberculosis Cost-effective Injection Plasmid Micro Manipulator Electroporator Anesthesia
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