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JoVE Journal Chemistry
Natural Product Discovery with LC-MS/MS Diagnostic Fragmentation Filtering
 

Natural Product Discovery with LC-MS/MS Diagnostic Fragmentation Filtering: Application for Microcystin Analysis

Article DOI: 10.3791/59712-v • 07:18 min • May 31st, 2019
May 31st, 2019 •
1, 2, 1, 1,2, 2
1Department of Chemistry, Carleton University Ottawa, 2London Research and Development Center, Agriculture and Agri-Food Canada

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résumé
Automatic Translation

Diagnostic fragmentation filtering, implemented into MZmine, is an elegant, post-acquisition approach to screen LC-MS/MS datasets for entire classes of both known and unknown natural products. This tool searches MS/MS spectra for product ions and/or neutral losses that the analyst has defined as being diagnostic for the entire class of compounds.

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Keywords: Natural Products Diagnostic Fragmentation Filtering LC-MS/MS Microcystin Cyanobacteria Toxin Analysis New Compound Discovery Software MZmine Mass Spectrometry Tandem Mass Spectrometry Sample Preparation
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