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Immunology and Infection

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JoVE Journal Immunology and Infection
Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection
 

Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection

Article DOI: 10.3791/64345-v • 08:40 min • August 23rd, 2022
August 23rd, 2022 •
1, 1, 1, 2, 2, 1, 3,4,5, 6, 2, 1
1UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 2Department of Biochemistry & Pharmacology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, 3Department of Microbiology & Immunology, University of North Carolina School of Medicine, 4Department of Surgery, University of North Carolina at Chapel Hill, 5Curriculum in Toxicology and Environmental Medicine, University of North Carolina at Chapel Hill, 6Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University

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A model mimicking the clinical scenario of burn injury and infection is necessary for furthering burn research. The present protocol demonstrates a simple and reproducible rat burn infection model comparable to that in humans. This facilitates the study of burn and infections following burn for developing new topical antibiotic treatments.

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Rat Burn Model Full-thickness Cutaneous Burn Infection Clinical Situations Immune Dysregulation Bacterial Infections Tropical Drugs Wound Healing Bacterial Infection Burn Induction Method Mouse Model Animal Models Anesthetized Rat Heating Pad Eye Lubricant Shave The Rat's Dorsal Area Electric Clipper Hair Removal Lotion Wet Gauze Sponge Isoflurane Recovery Cage Burn Injury Experiment Water Bath Temperature
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