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Immunology and Infection
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JoVE Journal Immunology and Infection
Granulocyte-dependent Autoantibody-induced Skin Blistering
 

Granulocyte-dependent Autoantibody-induced Skin Blistering

Article DOI: 10.3791/4250-v • 12:24 min • October 12th, 2012
October 12th, 2012 •
1, 2, 1,3
1Department of Dermatology, University of Freiburg, 2Kepler High School Freiburg, 3Centre for Biological Signalling Studies (BIOSS), University of Freiburg

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In the animal model described in our present work, purified IgG antibodies against a stretch of 200 amino acids (aa 757-967) of collagen VII are injected repeatedly into mice reproducing the blistering phenotype as well as the histo- and immunopathological features characteristic to human epidermolysis bullosa acquisita (EBA)1.

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Granulocyte-dependent Autoantibody-induced Skin Blistering Autoimmune Phenomena Self-tolerance Autoimmune Response Witebsky's Postulates Diagnosing Autoimmune Disease Passive Transfer Of Autoantibodies Epidermolysis Bullosa Acquisita (EBA) Experimental Models Collagen VII Blistering Phenotype Histo- And Immunopathological Features Human EBA Widespread Disease Dose Of Administered Collagen VII-specific IgG Tissue Damage Granulocyte Recruitment And Activation Inflammatory Pathway Autoimmune Tissue Damage
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