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Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration
 

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

Article DOI: 10.3791/60415-v • 10:53 min • October 13th, 2019
October 13th, 2019 •
1, 1, 2, 3, 3, 1
1Department of Biomedical Sciences, Korea University, 2Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, 3Department of Environmental Health, Harvard T.H. Chan School of Public Health

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Resumo
Automatic Translation

Collective cell migration in development, wound healing, and cancer metastasis is often guided by the gradients of growth factors or signaling molecules. Described here is an experimental system combining traction microscopy with a microfluidic system and a demonstration of how to quantify the mechanics of collective migration under biochemical gradient.

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Keywords: Traction Microscopy Microfluidics Collective Cell Migration Biochemical Gradient Cellular Forces PDMS SU-8 Mold Glass Slide Silanization Polyacrylamide Gel
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