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Genetics

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JoVE Journal Genetics
HOX Loci fokusert CRISPR/sgRNA biblioteket Screening identifisere kritiske CTCF grenser
 
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HOX Loci fokusert CRISPR/sgRNA biblioteket Screening identifisere kritiske CTCF grenser

Article DOI: 10.3791/59382-v • 10:10 min • March 31st, 2019
March 31st, 2019 •
1, 2, 2, 1, 1, 3, 1
1Department of Pediatrics, Pennsylvania State University College of Medicine, 2Department of Physiological Sciences, University of Florida, 3Department of Anatomy and Cell Biology, University of Florida

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En CRISPR/sgRNA bibliotek er utlignet til avhør protein-koding gener. Muligheten for et sgRNA-bibliotek for å avdekke funksjonen til en CTCF grense i genet regulering imidlertid uutforsket. Her beskriver vi et HOX loci bestemte sgRNA bibliotek for å belyse funksjon CTCF grenser i HOX loci.

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Genetikk problemet 145 CRISPR/Cas9 sgRNA biblioteket screening CTCF grensen HOX loci ettrinns RT-qPCR Indel mutasjon oppdagelsen akutt myelogen leukemi
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